KU57788

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01954CAS号：503468-95-9纯度：98%

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CAS号	503468-95-9	货号	BCP01954
中文名	KU57788
英文名	KU57788
中文别名
英文别名	KU 57788;NU-7441;KU-57788;NU7441;NU 7441;
SMILES
化学名称
分子式	C25H19NO3S	分子量	413.49
纯度	98%	配送	惯例下常温包邮
产品描述	NU7441 increases the persistence of γH2AX foci after ionizing radiation–induced or etoposide-induced DNA damage. NU7441 (0.5 μM or 1 μM) appreciably increases G2-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. NU7441 causes persistence of doxorubicin- and ionising radiation-induced DNA double-strand break and also slightly decreases homologous recombination activity DNA-PK-proficient M059-Fus-1 and DNA-PK-deficient M059 J human tumour cells. NU7441 inhibits UV-induced RPA p34 hyperphosphorylation in a dose-dependent manner both in cells lacking and cells expressing polymerase η. NU7441 increases levels of fludarabine-induced γH2AX foci and correspondingly decreased fludarabine-induced cell death in chronic lymphocytic leukemia cells. NU7441 also inhibits mitoxantrone-induced DNA-PKcs autophosphorylation and repair in chronic lymphocytic leukemia cells.