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CAS号 | 1201902-80-8 | 货号 | BCP02411 |
中文名 | 艾沙佐米柠檬酸盐 | ||
英文名 | Ixazomib Citrate | ||
中文别名 | |||
英文别名 | MLN-9708;MLN9708;MLN 9708; | ||
SMILES | B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl | ||
化学名称 | |||
分子式 | C20H23BCl2N2O9 | 分子量 | 517.12 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MLN9708 is a selective, orally bioavailable, second-generation proteasome inhibitor. MLN9708 has a shorter proteasome dissociation half-life and improved pharmacokinetics, pharmacodynamics, and antitumor activity compared with bortezomib, which we believe plays an important role in its improved tissue distribution. MLN9708 has a larger blood volume distribution at steady state, and analysis of 20S proteasome inhibition and markers of the unfolded protein response confirms that MLN9708 has greater pharmacodynamic effects in tissues than bortezomib. MLN9708 is a second-generation small-molecule proteasome inhibitor being developed for the treatment of a broad range of human malignancies.Upon exposure to aqueous solutions or plasma, MLN9708 rapidly hydrolyzes to its biologically active form MLN2238.MLN2238 is the biologically active form of MLN9708. |
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