艾沙佐米柠檬酸盐

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02411CAS号：1201902-80-8纯度：98%

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CAS号	1201902-80-8	货号	BCP02411
中文名	艾沙佐米柠檬酸盐
英文名	Ixazomib Citrate
中文别名
英文别名	MLN-9708;MLN9708;MLN 9708;
SMILES	B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl
化学名称
分子式	C20H23BCl2N2O9	分子量	517.12
纯度	98%	配送	惯例下常温包邮
产品描述	MLN9708 is a selective, orally bioavailable, second-generation proteasome inhibitor. MLN9708 has a shorter proteasome dissociation half-life and improved pharmacokinetics, pharmacodynamics, and antitumor activity compared with bortezomib, which we believe plays an important role in its improved tissue distribution. MLN9708 has a larger blood volume distribution at steady state, and analysis of 20S proteasome inhibition and markers of the unfolded protein response confirms that MLN9708 has greater pharmacodynamic effects in tissues than bortezomib. MLN9708 is a second-generation small-molecule proteasome inhibitor being developed for the treatment of a broad range of human malignancies.Upon exposure to aqueous solutions or plasma, MLN9708 rapidly hydrolyzes to its biologically active form MLN2238.MLN2238 is the biologically active form of MLN9708.