艾泼米辛新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP13740CAS号：134381-21-8纯度：98%

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CAS号	134381-21-8	货号	BCP13740
中文名	艾泼米辛
英文名	Epoxomicin
中文别名	埃泼米辛;
英文别名	BU-4061T;
SMILES	O=C([C@@H](NC([C@H]([C@@H](C)O)NC([C@@H](NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)[C@@]1(C)CO1
化学名称
分子式	C28H50N4O7	分子量	554.72
纯度	98%	配送	惯例下常温包邮
产品描述	Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM. By inhibiting osteoblast proteasome activity, epoxomicin stimulates bone formation at concentrations as low as 10 nM. Intraperitoneal injection of 1.5 mg/kg epoxomicin given daily for two weeks induces Parkinson's-like symptoms in rats and addition of 100 nM epoxomicin to rat ventral midbrain cultures results in apoptosis specific to dopaminergic neurons. Epoxomicin-induced parkinsonism can be a useful model to examine mechanisms and therapies for the disease.

艾泼米辛 新