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CAS号 | 1354825-58-3 | 货号 | BCP23889 |
中文名 | WEHI-345 | ||
英文名 | WEHI-345 | ||
中文别名 | |||
英文别名 | WEHI345; WEHI 345; | ||
SMILES | |||
化学名称 | |||
分子式 | C22H23N7 | 分子量 | 401.47 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. Despite only delaying NF-κB activation on NOD stimulation, WEHI-345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. |
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