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| CAS号 | 2226735-55-1 | 货号 | BCP30590 |
| 中文名 | GSK547 | ||
| 英文名 | GSK547 | ||
| 中文别名 | |||
| 英文别名 | GSK-547; GSK 547; RIP1i; | ||
| SMILES | C1CN(CCC1C(=O)N2C(CC=N2)C3=CC(=CC(=C3)F)F)C4=NC=NC(=C4)C#N | ||
| 化学名称 | |||
| 分子式 | C20H18F2N6O | 分子量 | 396.40 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo; exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963; reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner. RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA). | ||
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