RN983 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44110CAS号：1423129-83-2纯度：98%

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CAS号	1423129-83-2	货号	BCP44110
中文名	RN983
英文名	RN983
中文别名
英文别名	RN-983; RN 983;
SMILES	CC(C)(C)C1=CC2=C(C(=C1)F)C(=O)N(N=C2)C3=NC=CC(=C3CO)C4=NN(C(=O)C(=C4)NC5=NC=C(C=C5)C6CCN(CC6)C)C
化学名称
分子式	C34H37FN8O3	分子量	624.71
纯度	98%	配送	惯例下常温包邮
产品描述	RN983 is a potent and selective BTK inhibitor. RN983 potently, selectively, and reversibly inhibited the Btk enzyme. RN983 displayed functional activities in human cell-based assays in multiple cell types, inhibiting IgG production in B-cells with an IC50 of 2.5 ± 0.7 nM and PGD2 production from mast cells with an IC50 of 8.3 ± 1.1 nM. RN983 displayed similar functional activities in the allergic mouse model of asthma when delivered as a dry powder aerosol by nose-only inhalation. Inhalation of aerosolized RN983 may be effective as a stand-alone asthma therapy or used in combination with inhaled steroids and β-agonists in severe asthmatics due to its potent inhibition of mast cell activation.