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| CAS号 | 1469988-75-7 | 货号 | BCP30763 |
| 中文名 | QL47 | ||
| 英文名 | QL47 | ||
| 中文别名 | |||
| 英文别名 | QL 47; QL-47; QL-XII-47; | ||
| SMILES | CN1C=C(C=N1)C2=CC3=C4C(=CN=C3C=C2)C=CC(=O)N4C5=CC6=C(CCN6C(=O)C=C)C=C5 | ||
| 化学名称 | |||
| 分子式 | C27H21N5O2 | 分子量 | 447.49 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | QL47, also known as QL-XII-47, is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations. | ||
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