Tolebrutinib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP33289CAS号：1971920-73-6纯度：98%

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CAS号	1971920-73-6	货号	BCP33289
中文名	Tolebrutinib
英文名	Tolebrutinib
中文别名
英文别名	SAR442168; SAR-442168; SAR 442168;
SMILES	C=CC(=O)N1CCCC(C1)N2C3=C(C(=NC=C3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5
化学名称
分子式	C26H25N5O3	分子量	455.51
纯度	98%	配送	惯例下常温包邮
产品描述	Tolebrutinib is an orally bioavailable, brain-penetrant, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, tolebrutinib is able to cross the blood-brain barrier and inhibits the activity of BTK both peripherally and in the central nervous system (CNS). This prevents the activation of the B-cell antigen receptor (BCR) signaling pathway, and the resulting immune activation and inflammation. The inhibition of BTK activity also prevents microglial inflammatory signaling in the CNS, and the resulting immune activation, neuroinflammation and neurodegeneration. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. In addition to B cells, BTK is also expressed in innate immune cells, including macrophages and microglia, and plays an important role in the regulation of microglial inflammatory signaling.