VX-984

参考资料仅供科学研究，不可用于个人用途。

货号：BCP29319CAS号：1562396-65-9纯度：98%

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CAS号	1562396-65-9	货号	BCP29319
中文名	VX-984
英文名	VX-984
中文别名
英文别名	VX 984; VX984; M9831; M-9831; M 9831;
SMILES	O=C(C1=CC=NC2=C([C@H](C)CNC3=NC=NC(C4=C([2H])N=C(C)N=C4[2H])=C3)C=CC=C12)N
化学名称
分子式	C22H19D2N7O	分子量	401.46
纯度	98%	配送	惯例下常温包邮
产品描述	VX-984, also known as M9831, is an ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase (DNA-PK), with potential sensitizing and enhancing activities for both chemo- and radiotherapies. Upon administration, VX-984 binds to and inhibits the catalytic subunit of DNA-PK, thereby interfering with the non-homologous end joining (NHEJ) process and preventing repair of DNA double strand breaks (DSBs) caused by ionizing radiation or chemotherapeutic treatment. This increases chemo- and radiotherapy cytotoxicity and leads to enhanced tumor cell death. The enhanced ability of tumor cells to repair DSBs plays a major role in the resistance of tumor cells to chemo- and radiotherapy; DNA-PK plays a key role in the NHEJ pathway and DSB repair.