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CAS号 | 1899921-05-1 | 货号 | BCP38312 |
关联产品 | 2134096-03-8(阿美替尼盐酸盐) 2134096-06-1(阿美替尼甲磺酸盐) | ||
中文名 | 阿美替尼 | ||
英文名 | Almonertinib | ||
中文别名 | |||
英文别名 | HS-10296; HS 10296; HS10296; | ||
SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC | ||
化学名称 | |||
分子式 | C30H35N7O2 | 分子量 | 525.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Almonertinib is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. |
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