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CAS号 | 2134096-06-1 | 货号 | BCP48089 |
关联产品 | 2134096-03-8(阿美替尼盐酸盐) 1899921-05-1(阿美替尼) | ||
中文名 | 阿美替尼甲磺酸盐 | ||
英文名 | Almonertinib mesylate | ||
中文别名 | 甲磺酸阿美替尼; | ||
英文别名 | HS-10296 mesylate;HS10296 mesylate;HS 10296 mesylate; | ||
SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O | ||
化学名称 | |||
分子式 | C31H39N7O5S | 分子量 | 621.76 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Almonertinibmesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer. |
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