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| CAS号 | 267243-28-7 | 货号 | BCP01790 |
| 关联产品 | 289499-45-2（卡奈替尼两盐酸盐） | ||
| 中文名 | 卡奈替尼 | ||
| 英文名 | Canertinib | ||
| 中文别名 | 卡那替尼;卡纽替尼;卡拉替尼; | ||
| 英文别名 | PD-183805;CI1033;CI-1033;CI 1033;PD 183805;PD183805; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C24H25ClFN5O3 | 分子量 | 485.94 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Canertinib, also known as CI1033 and PD183805, is a potent ErbB inhibitor for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions. Also, canertinib is not an inhibitor of OATP-1B1 or OATP-1B3 transporter. | ||
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