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| CAS号 | 1086639-59-9 | 货号 | BCP28812 |
| 中文名 | Y 11 | ||
| 英文名 | Y 11 | ||
| 中文别名 | |||
| 英文别名 | Y11; Y-11; | ||
| SMILES | O[C@@H]1[C@@H]([C@](O[C@]1NC(N(CC(O)=O)C)=N)CO)O | ||
| 化学名称 | |||
| 分子式 | C8H17BrN4O | 分子量 | 265.15 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3. | ||
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