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| CAS号 | 761437-28-9 | 货号 | BCP06482 |
| 中文名 | NVP TAE226 | ||
| 英文名 | NVP TAE226 | ||
| 中文别名 | |||
| 英文别名 | NVPTAE226;NVP-TAE226;TAE226;TAE226;TAE 226; | ||
| SMILES | O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC | ||
| 化学名称 | |||
| 分子式 | C23H25ClN6O3 | 分子量 | 468.94 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | NVP-TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration-dependent decrease in cellular proliferation with an associated G(2) cell cycle arrest in every cell line and an increase in apoptosis in a cell-line-specific manner. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix. | ||
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