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mAChR

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mAChR

结构式 货号 产品名称 CAS号
ARL 14495 结构式
 BCP23970 ARL 14495 123319-03-9
ARL 14495 is a rigid M1/M3 muscarinic agonist affecting acetylcholine activity, used often in the treatment of Alzheimer’s disease.
Otenzepad 结构式
 BCP24273 奥腾折帕 100158-38-1
Otenzepad is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.
4-DAMP 结构式
 BCP49007 4-二苯乙酰氧基-N-甲基-哌啶甲碘化物 1952-15-4
4-DAMP is a potent antagonist of M3 receptor and also has a high affinity for the closely-related M5 receptor.
Emraclidine 结构式
 BCP48520 Emraclidine 2170722-84-4
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator.
VU0467154 结构式
 BCP47001 VU0467154 1451993-15-9
VU0467154 is a potent and selective M4 PAM. VU0467154 exhibits robust APD-like and cognitive enhancing activity in rodents. Selective M4 PAMs could provide a therapeutic strategy for the treatment of HD.
Deschloroclozapine 结构式
 BCP46891 去氯氮平 1977-07-7
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
Diphemanil Methylsulfate 结构式
 BCP44336 甲硫二苯马尼 62-97-5
Diphemanil Methylsulfate is a quaternary ammonium anticholinergic.It binds muscarinic acetycholine receptors (mAchR).
Nebracetam 结构式
 BCP44037 奈拉西坦 116041-13-5
Nebracetam, a nootropic M1-muscarinic agonist, induces a rise of intracellular Ca2+ concentration.
Sofpironium bromide 结构式
 BCP43183 Sofpironium Bromide 1628106-94-4
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
VU0453595 结构式
 BCP43186 VU0453595 1432436-13-9
VU0453595 is a novel M1 positive allosteric modulator (PAM), potential in schizophrenia.
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