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Phosphatase

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Phosphatase

结构式 货号 产品名称 CAS号
Rosiptor acetate 结构式
 BCP24919 Rosiptor acetate 782487-29-0
Rosiptor is a potent and selective SHIP1 activator. AQX-1125 inhibits Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduces cytokine production in splenocytes, inhibits the activation of mast cells and inhibits human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy.
Raphin1 acetate 结构式
 BCP48942 Raphin1 acetate 2242616-04-0
Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
Raphin1 结构式
 BCP48938 Raphin1 2022961-17-5
Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
5-FAM tetrazine 结构式
 BCP48732 5-羧基荧光素-四嗪 1402432-77-2
NUN17724 结构式
 BCP47020 NUN17724 765317-72-4
NUN17724 is a specific inhibitor of protein tyrosine phosphatase 1B (PTP1B).
Razuprotafib 结构式
 BCP46999 雷罗他非 1008510-37-9
Razuprotafib, also known as AKB-9778, is a small-molecule inhibitor restoring Tie2 activation by inhibiting VE-PTP. In investigations against diabetes and COVID-19, razuprotafib is self-administered by patients through subcutaneous injection.
MP07-66 结构式
 BCP46434 MP07-66 1938056-90-6
MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.
ABBV-CLS-484 结构式
 BCP45961 ABBV-CLS-484 2489404-97-7
ABBV-CLS-484 is a novel, orally bioavailable PTPN2 inhibitor for treatment of advanced or metastatic tumors.
SBI-425 结构式
 BCP45955 SBI-425 1451272-71-1
SBI-425 is a potent, selective and orally bioavailable compound that robustly inhibits tissue-nonspecific alkaline phosphatase (TNAP) in vivo.
BVT948 结构式
 BCP45529 BVT948 39674-97-0
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).
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