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Protease/Metabolic Enzyme

结构式 货号 产品名称 CAS号
Ninerafaxstat 3HCl 结构式
 BCP49659 Ninerafaxstat 3HCl 2311824-72-1
Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereby inhibiting the proliferation and growth of cancer cells.
ZK53 结构式
 BCP49658 ZK53 3031789-26-8
ZK53 is a selective and potent activator of mitochondrial casein hydrolase protease P (HsClpP).ZK53 induces apoptosis and inhibits the hydrolysis of alpha-casein by HsClpP.ZK53 inhibits tumour growth in xenografts and native mouse models.
BMS-502 结构式
 BCP49646 BMS-502 2407854-18-4
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM.
SI113 结构式
 BCP49628 SI113 1392816-46-4
SI113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy.
5-LOX-IN-1 结构式
 BCP49611 5-LOX-IN-1 55040-82-9
5-LOX-IN-1 is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM.
hCAIX-IN-5 结构式
 BCP49610 hCAIX-IN-5 2451479-57-3
hCAIX-IN-5 is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively.
Lonodelestat 结构式
 BCP49598 环状抑制剂多肽 906547-89-5
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).
BAY-179 结构式
 BCP49597 BAY-179 2764880-87-5
BAY-179 is a potent, selective, and species cross-reactive OXPHOS complex I inhibitor.
Cbl-b-IN-3 结构式
 BCP49568 Cbl-b-IN-3 2573775-59-2
Cbl-b-IN-3 is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM.
ASC-42 结构式
 BCP49481 ASC-42 ASC-42
ASC 42 is a selective, non-steroidal, potent Farnesoid X Receptor (FXR) agonist.
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