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Ras/Rho

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Ras/Rho

结构式 货号 产品名称 CAS号
KRAS G12D inhibitor 18 结构式
 BCP49689 KRAS G12D inhibitor 18 2922732-54-3
KRAS G12D inhibitor 18 is a potent KRAS G12D inhibitor.
RMC-7977 结构式
 BCP49669 泛KRAS抑制剂 2765082-12-8
RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.
BI-2493 结构式
 BCP49649 BI-2493 2937344-16-4
BI-2493 is a structural analogue of BI-2865 that was optimized for in vivo administration.
RAS-IN-2 结构式
 BCP49648 RAS-IN-2 2765081-21-6
RAS-IN-2 (RMC-6236) is a potent pan-KRAS inhibitor targeting activation-state KRAS for cancer-related studies.
BI-0474 结构式
 BCP49602 BI-0474 2750570-55-7
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
BI-2865 结构式
 BCP49601 BI-2865 2937327-93-8
BI-2865 is a pan-KRAS inhibitor. BI-2865 inhibited the proliferation of isogenic G12C, G12D or G12V mutant KRAS expressing BaF3 cells more potently than precursor 1 with a mean IC50 of roughly 140 nM.
D3S-001 结构式
 BCP49226 D3S-001 D3S-001
D3S-001 is a potent and highly differentiated KRAS G12C inhibitor, which demonstrates rapid and near complete target inhibition and strong anti-tumor activity in preclinical cell line and animal models.
MLS000532223 结构式
 BCP48911 MLS000532223 16616-39-0
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases. It prevents GTP binding to several GTPases. Small GTPases are key regulators of cellular activity .
AMG 510 Racemate 结构式
 BCP30799 AMG 510 Racemate AMG510Racemate
RM-018 结构式
 BCP48790 RM-018 2641993-55-5
RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C.
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